The closed environment of a purse makes it the perfect breeding ground for mold when something gets spilled inside. The only way to preserve your accessory is to clean it out as soon as possible. Even liquids such as water will cause damage. Unfortunately, it's not just the purse lining you must worry about. Everything inside has the potential to get wet, as well. Fluid leaks through the material and can damage the outside of the bag, too. Cleaning a purse when something gets spilled requires attacking the problem both inside and out.
Empty out the content of the purse onto a towel. Sort through your belongings, and separate the items affected by the liquid. Wipe down any item soiled from the spill with a paper towel. If the mess is sticky, you may need to clean the item with soapy water. Leave the contents of the purse on the towel until everything dries.
Wipe out the inside of the purse with paper towels. Depending on the viscosity of the liquid spilled, you may be able to wipe it all up with towels. For instance, you can wipe up a water spill with the paper towels, but for thicken fluids, you'll need to scoop out the mess first -- before trying to wash the inside of the purse.
Wet a cleaning rag with soapy water. Clean both inside and outside of the purse with a mild dish washing soap. For a leather purse, use leather cleaner on the outside of the bag, following the label's directions for proper application.
Dry the inside and outside of your bag with a clean towel. Pull the lining up and out of the bag opening. Allow it to hang out of the purse as much as possible. Set your purse aside until it dries thoroughly. Once clean and dry, you can put the contents back into the purse.