Your doctor or urologist may recommend a prostate biopsy if your blood tests or rectal exam yield any abnormal results. During the procedure, a probe is inserted into your rectum to allow the doctor to visualize your prostate. A small needle is placed into the probe to allow the doctor to quickly obtain several specimens from your prostate for microscopic study. Because the procedure is performed rectally, it is necessary to cleanse the area with a Fleet enema to avoid any contamination of the biopsy area.

Administering an Enema

Administer the Fleet enema at home on the morning of your biopsy. You can buy Fleet enemas at any superstore or your local pharmacy. Take the package into your bathroom and perform the procedure while sitting on the toilet.

Remove the enema from the packaging and take the protective shield off of the tip of the enema. Using steady, gentle pressure, insert the tip of the enema into your rectum using a vague sideways motion. The tip of the enema should be facing your belly button. Simulate having a bowel movement for easier insertion. Bearing down will help relax your anal muscles.

Squeeze the enema bottle, emptying all (or nearly all) of the liquid. Remove the enema from your rectum but remain in position. Within 5 minutes you will have a strong urge to have a bowel movement.

Remain on the toilet until you are finished emptying your bowels. Once you are completely finished, dispose of the enema and take a thorough shower to prepare for your upcoming prostate biopsy.


Tell your doctor if you have any medical conditions or allergies. If you have kidney problems, hypertension (high blood pressure), bladder infection, colostomy, vomiting, nausea, appendicitis, bone or muscle problems, or pancreas problems, you may experience an adverse reaction to a Fleet enema.

Talk to your doctor about all medications you are taking (including over-the-counter medication, vitamins and herbal supplements) to avoid any drug interactions.

Fleet enemas are generally well tolerated. Common side effects include irritation of the rectum, diarrhea, abdominal cramping, nausea and gas.


Forcing the enema into your rectum may cause injury.

No more than one enema should be used in a 24-hour period.

If you notice any rectal bleeding or if you do not have a bowel movement after administering the enema, contact your doctor immediately.

Tell your doctor if you are pregnant or breastfeeding as there are potential risks involved.