While Ziana gel is specifically marketed as a topical gel treatment for acne, according to Leslie Baumann, MD, at YahooHealth.com, one of the key active ingredients in the product also gives it significant anti-aging properties. Baumann notes that Ziana contains Tretinoin, a prescription-strength retinoid, and retinoids are currently one of the most popular weapons dermatologists have for slowing the skin’s aging process and improving existing signs of aging like fine lines and wrinkles.


Under its generic name, Ziana is listed as clindamycin phosphate and tretinoin. It is a gel product that combines two active ingredients: an antibiotic and a retinoid. The retinoid component of the product, Tretinoin, generates hyaluronic acid and collagen production in the skin, giving the skin a firmer, fuller appearance. It’s also an exfoliator that improves a skin’s texture and tone while simultaneously encouraging cell turnover to reduce brown spots and discolorations.


According to Dr. Baumann, dermatologists are starting to prescribe Ziana for a variety of skin issues. Although reviews at DailyBeauty are from new users of the product, making results inconclusive, some users indicate that their dermatologists are now prescribing Ziana for more than acne treatment. In addition to its acne-fighting benefits, it exfoliates and plumps the skin, reduces hyperpigmentation and encourages a more radiant, healthy glow on the skin.

Side Effects/Interaction

Erythromycin-containing products can interact with Ziana and reduce the effectiveness of both products since they are both antimicrobials, according to drugs.com. Using Ziana while taking neuromuscular blocking agents can amplify the effects of both drugs, so they shouldn’t be used together. Ziana can make skin more sensitive to soaps, cleansers or cosmetics that are harsh, abrasive or medicated. Contact your physician if your skin becomes crusty, blistered, red or swollen after taking Ziana, or you develop watery or bloody diarrhea.


The manufacturers of Ziana caution consumers with Crohn’s disease, ulcerative colitis, or any history of bowel or digestive issues to discuss those conditions with their physician before beginning a regimen of Ziana. In addition, since Ziana contains an antibiotic, anyone who has developed colitis with past antibiotic use is not a good candidate for Ziana. Pregnant women, nursing mothers and children under 12 are not encouraged to use Ziana as either an acne or anti-aging treatment.

Expert Insight

Retinoids, indicates Dr. Braumann, are typically prescribed for patients with acne problems because they exfoliate the dead facial skin cells that can cause blocked pores and lead to acne. However, dermatologists have discovered that acne patients treated with retinoids for acne lesions had fewer dark spots and wrinkles than patients not treated with retinoids. Due to this development, more and more dermatologists are now prescribing acne treatments with retinoids for anti-aging purposes.