Perfume vials come in all shapes and sizes, and they have been part of human civilization for millennia -- some are even more than 4,000 years old. Egyptians began using glass for perfume vials in 1500 B.C. Contemporary vials can be high art. But there are also vials sold by the millions for samples. Modern vials are usually made of glass and consist of the vial itself and a stopper.
Inspect the vial. Decorative bottles typically have a stopper that is used to prevent the perfume from evaporating some of its more volatile scents. Nearly all vials that are used for samples are screw top.
Grasp the base with one hand. You don't want to spill perfume when you're doing this, so its safer to keep a hand on the bottom.
Remove the top. If you're opening the type of vial with a stopper, lift straight up. Otherwise, unscrew the lid.