Calzones resemble folded-over pizzas, and like pizza, they taste best when they're piping-hot out of the oven. Leftover calzones can be reheated without drying out the center or making the crust soggy. How long it takes to reheat your calzone will depend on the amount of filling and whether you had your calzone stored in the freezer or refrigerator.
Heat the oven to 400 degrees Fahrenheit for 20 minutes.
Place the calzone directly from the refrigerator, unwrapped, onto a baking sheet. Wrap frozen calzones with aluminum foil before putting them on a baking sheet.
Bake the calzone for 15 to 18 minutes.
Insert the probe of a food thermometer into the center of the calzone and check that the temperature is at least 165 degrees Fahrenheit. The crust should be golden brown.
Not heating leftovers to 165 F can lead to foodborne illness.